Dr Mohammad Askandar Iqbal and his team at the Department of Biotechnology, Jamia Millia Islamia(JMI), discovered the antagonistic roles of CBX2 and CBX7 genes in regulating glucose utilization in breast cancer cells. The discovery has enabled them to identify drugs that could be more effective in treating breast cancer patients with higher CBX2 and lower CBX7 expression.
Using a large amount of diverse molecular data from more than 3000 breast cancer patients along with gene silencing experiments, Dr Iqbal’s team identified the pro-cancer role of CBX2 and the anticancer role of CBX7, based on their effects on glucose metabolism in breast cancer.
Dr Iqbal and team also found that breast cancer patients with higher CBX2 and lower CBX7 expression in their tumors showed lesser survival probability compared to those having the reverse trends of expression of these two genes.
Highlighting the biological relevance of findings, CBX2 gene was found to be expressed at higher levels in breast cancer compared to normal breast tissue, whereas, the exact opposite trend was observed for CBX7. Further, the study reported that more deadly cancer tends to express higher levels of CBX2 and lower CBX7.
This research entitled “Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer” is published in Molecular Oncology, one of the most reputed journal worldwide in the field of oncology- a branch of medical science dealing with the study of cancer.
his is the first part of the series called-Scientist Says-where we would be presenting research works of young scientists in various fields.
Khadija Kanwal Khanum has done her PhD and Postdoctoral fellow from Indian Institute of Science (IISc), Bengaluru, India (2010-2018). Presently, she is a postdoctoral fellow at the University of Waterloo, Waterloo, Canada. She shares with Rashida Bakait of India Tomorrow, her significant studies and research on “Solar Cells’’.
Q. What was the topic of your research at IISc and a brief explanation about the same?
Ans. The broad topic of my doctoral and postdoctoral research at Indian Institute of science, Bengaluru, was fabrication, characterization and analyses of organic and hybrid photovoltaics (solar cells) to enhance the solar cell’s device performances. Specifically, the title of my doctoral thesis was “Morphological Architecturing of electroactive materials in organic electronics”. In this research, organic and organic-inorganic (hybrid) semiconductor/electroactive materials are used, instead of inorganic semiconductor materials/silicon to fabricate the solar cells. The organic and hybrid materials compare to the inorganic materials/ silicon counterparts are lab synthesized materials with ability to easily tailor the band gap (as semiconductors), and require less energy during their solar cell fabrication hence cost-effective. However, these organic and hybrid solar cells have till now reported, less power conversion efficiency, PCE (>25%) and are less stable in environment and therefore, require extensive research before their wide commercialization.
Q. What was the aim behind your research?
Ans. In this research, a different fabrication procedure was used called Electro-spinning, in order to enhance the light absorption as well as increase the charge (electron-hole) separation in the solar device, thereby increasing its PCE.
Q. What kind of new aspects were highlighted in your research?
Ans. The highlighting parts of the research were 1).The active layer of the solar cell which is generally in a thin film form was modified to fiber and various other forms such as network (Khanum and Ramamurthy, 2016), photonic (Khanum et al., 2017), two and three-dimensional triangles (Khanum and Ramamurthy, 2018) and spike-spheres (Khanum et al., 2015) structures using electrospinning/ electrospraying method. 2). The modified active layers assisted in improving the solar devices’ light absorption by 19 – 31% and PCE by 23 – 68%.
Q. When did you begin and complete your research?
Ans. I joined IISc as a doctoral student, in Aug 2010 and subsequently took few advance and elective courses in polymer science and technology, nanotechnology, vacuum systems, sensors and material characterization for one year, in order to gain knowledge and understanding of the above subjects, which helped me in my research. I started my research sometime around June 2011, submitted my doctoral thesis in July 2015, defended the thesis in July 2016, and continued the research as research associate and postdoctoral fellow till Mar 2018.
Q. What kind of challenges you faced?
Ans. Since organic electroactive materials used in this research are conjugated small molecules and polymers possessing, low molecular weight than conventional polymers hence, fiber formation using electrospinning was difficult. Therefore, lot of optimization of the electrospinning process parameters and modifications of the organic and hybrid materials used such as; preparation time, concentration and solvent used had to be meticulously carried out, during solar cells fabrication. Additionally, maintaining inert atmosphere both, during fabrication and characterization of solar cells required lot of patience and cautions, making this study iterative and time-consuming. For instance, it took almost two years in this study, to obtain first few successful solar cell devices.
Q. Any scholarships or awards for research?
Ans. For my PhD and postdoctoral research, major part of the funding was received as scholarship from Ministry of Human Resource Development (MHRD) and Institute (IISC) research associate fund while during last 15 months; I received scholarship from my Ph.D and Postdoctoral advisor from his project grant. I received few awards and grants to present the research work in various international conferences; Manish Narayan memorial award from Department of Materials Engineering, IISc in 2014, Indian Institute of Science support and grant in 2014 and 2015, Department of Science and Technology (DST) young scientist in 2016 and International Workshop on Advanced Materials (IWAM), Ras Al Khaimah, UAE travel grant in 2016 and 2018.
Q. How do you think your research would be beneficial to industry/ society?
Ans. Energy from sun that strikes the earth in a year is enormous, precisely equals to 3 x 1024 J, or about 10, 000 times more than current global energy consumption. Covering 0.1% of the earth’s surface with 10% efficiency solar cells would suffice the energy demand of the whole world (Siddiki et al., 2010). Therefore, my research of improving the light absorption and PCE of organic and hybrid solar cells through morphological architecturing would be one of the smart tools that can be used to trap and utilize the renewable and sustainable energy resource (solar energy).
Q. What was the conclusion of your research?
Ans. In conclusion, in this research `Electrospinning Processing Technique’ is evaluated as one of the novel processing techniques for morphology patterning, leading to improvements in structural, optical and opto-electrical properties of organic and hybrid electroactive materials. Further these electroactive materials based on morphological patterning were also evaluated as organic solar cells with 19 – 31% increment in light/ optical absorption and 23 – 68% enhancement in PCE (Khanum and Ramamurthy, 2016; Khanum et al., 2017; Khanum and Ramamurthy, 2018).
Q. How do you think your research can be carried forward?
Ans. The research could be extended in studying the life stability and field performance of these solar cells. The research could also be extended by using electrospinning processing technique to generate more morphological structures than studied in this research (mentioned in Q3’s reply) and evaluate their properties in the field of photovoltaics/solar devices. The already generated morphological structures such as network, photonic, two and three-dimensional triangles and spike-spheres structures are made up of organic electroactive materials and can be explored in the field of sensors and medical applications as in drug delivery and as tissue scaffolds, therefore the feasibility in these areas could also be one of the future direction.
Q. Can you brief us about your current research?
Ans. Yes, my research at University of Waterloo, Canada is on nanocomposites materials employed in power industry. As the World’s energy demand seems to be all time high and increasing, the focus of research is now more on renewable and sustainable energy. The power industry needless to mention, acts as a bridge between all types of energy generation and the consumers. In my present work, the importance of nanocomposites materials and its processing with respect to power industry are researched. Nanocomposites are remarkable class of materials, consisting of various types of nanofillers which act as reinforcement in the matrix and thus enhance the desired properties. These nanomaterials have to be dispersed homogeneously in the matrix to gain optimized effects and therefore require special processing tools. Therefore, in this research, processing of various polymer nanocomposites of silicone filled with Silica and Alumina fillers are studied.
Q. Apart from your main research topic, would you like to list any other work you collaborated and worked on?
Ans. Yes, besides fabrication, characterization and analyses of organic and hybrid solar cells, I collaborated and worked on few other interesting topics such as– Developed silk and melanin nanofibers mats for the bio-application such as scaffolds for tissue engineering, evaluated the effectiveness of non-water based cleaning mechanisms for photovoltaic (PV) systems. Studied the influence of dust density and composition on performance of PV systems using Infrared (IR) radiation and assessed magnetic materials and their integration in fibre reinforced polymer composites for structural applications.
source: http://www.indiatomorrow.net / India Tomorrow / Home> Education / by Rashida Bakhait, India Tomorrow / March 17th, 2021
In his career spanning over 60 years, Shah Manzoor Alam moved to Hyderabad in 1950 when job openings appeared in the Osmania university (OU).
Former vice-chancellor of Kashmir University, Srinagar and the former head department of geography Osmania University, Shah Manzoor Alam, 93. (Photo supplied)
Hyderabad:
Renowned professor—former vice-chancellor of Kashmir University, Srinagar and the former head department of geography Osmania University, Shah Manzoor Alam, 93, has passed away of a cardiac arrest on Tuesday evening at his residence in Hyderabad.
A native of Ghazipur, Uttar Pradesh, Alam did his early schooling in Gorakhpur. He did his bachelor’s and masters in arts from Aligarh Muslim University (AMU).
In his career spanning over 60 years, Shah Manzoor Alam moved to Hyderabad in 1950 when job openings appeared in the Osmania university (OU) and joined the university as lecturer in geography in evening college.
In the mid-1960s, he became the head of the geography department in the arts college of the Osmania University (OU). Subsequently went to the United Kingdom to do a Doctor of Philosophy (PhD) from Edinborough.
In the year 1972, Manzoor Alam was invited to Australia as a visiting professor and later to New Zealand in 1974.
Shah Manzoor Alam was a vice chancellor (VC) of Kashmir university, Srinagar from 1984-1987.
In 1992 he was invited by the Al-Imam Mohammed ibn Saud university, Riyadh to work on the scientific significance in selected Quranic verses.
He was responsible for establishing a trust called Mustafa Educational Network trust. The trust had brought out a set of 30 monographs related to different aspects of Islam.
In 2004, he was key to establishing the Indian school of excellence trust that would provide quality education combined with human values at an affordable cost. A school under this trust was set up at Tolichowki and became functional in June 2004.
Professor Alam lost his wife to heart disease in 1998, lost his only son Shah Shahab Alam to lung cancer in 2013. In spite of these severe personal losses, his strong faith kept him going till he breathed his last on the evening of June 22 due to cardiac failure.
Professor Shah Manzoor Alam is survived by three daughters Rana Siddiqi (USA), Rumana Ahmed (Hyderabad), Rubab Ali Fareed (USA).
MANUU pays tributes
Maulana Azad National Urdu University (MANUU) on Thursday paid rich tributes to Professor Shah Manzoor Alam.
Prof Manzoor Alam was also closely associated with MANUU in it’s formative years as the member of it’s first executive council. He played an important role in the development of MANUU in its initial days.
Prof Alam who was also the founder director of centre for area studies on the Indian ocean region, OU was also awarded the prestigious, ‘BHOOGOL RATNA AWARD’ for 2017 by NAGI (National Association of Geographers India), New Delhi, during the 39th, Indian geography congress (IGC) held at Osmania University.
Shah Manzoor Alam awarded the prestigious, ‘BHOOGOL RATNA AWARD’ for 2017 by NAGI (National Association of Geographers India), New Delhi
Professor S M Rahmatullah, Vice-Chancellor and Professor Siddiqui Mohd Mahmood, Registrar in their message expressed their condolences to bereaved family members.
source: http://www.siasat.com/ The Siasat Daily / Home> News> Hyderabad News / by Sakina Fatima / June 25th, 2021
However, the Social Data Initiatives Forum (SDIF) of Hyderabad helped those from rural and tribal places of Telangana.
Khalid Saifullah, a member of SDIF (Photo/ANI) / aninews.in
Hyderabad:
Keeping in view the limited access of medical facilities in the rural and tribal parts of the society amid the COVID pandemic, a Hyderabad based non-profit organization (NGO) has combined both the fields of service and technology together to extend their help to those from inaccessible areas of the state.
While there are several NGOs and individuals who have stepped forward to do their part in the pandemic, most have limited themselves to the cities and urban establishments.
However, the Social Data Initiatives Forum (SDIF) of Hyderabad helped those from rural and tribal places of Telangana.
Speaking about the initiative, Mohammad Azam Khan, the Founder and Director of SDIF said that since the inception of the COVID-19 Pandemic, the organisation had been working at several hospitals and couldn’t help but notice that many people admitted in Hyderabad were from nearby rural areas.
“Looking at the condition of people from rural areas that came to Hyderabad in search of proper medical treatment but were unable to find a bed or Oxygen while their health deteriorated, we decided that medical assistance like oxygen should be provided to them at their place instead of them having to look for it in the cities,” he said.
Azam further mentioned that to achieve this, the NGO publicised their contact and helpline numbers and was able to set up Oxygen banks at several district headquarters and Government hospitals from where those who were in need could collect oxygen free of cost.
“To further speed up the supply of oxygen we requested the people to place a request of their requirement through the organisation’s website so that we can deliver oxygen to their doorstep,” he said. SDIF has recently started collaborating with several other NGOs of other states and at the district, levels to ensure support to the people from the rural backdrop.
Khalid Saifullah, a member of SDIF he mentioned that the organisation developed a digital program that interacts with the Application Programming Interface (API) of Twitter, which works on Search Engine Optimization (SEO) to identify tweets that have words like ‘Need Help, Oxygen’.
“Those people are contacted to cross-check the requirement and then we help them in receiving Oxygen from the nearest available source”, he added.
Khalid said, “During the peak days of the pandemic, there were about 150 to 200 requests; we ensured all requests were fulfilled.”
source: http://www.siasat.com / The Siasat Daily / Home> News> Hyderabad News / by ANI / posted by Sakina Fatima/ June 17th, 2021
This is the sixth part of the series – `Scientist Says’ – where we bring for our readers the significant and commendable research works of young scientists in various fields.
Dr. Imtiyaz Ahmad Bhat started working as a researcher in the year 2013 with Prof. P.S Mukherjee lab, Inorganic and Physical Chemistry department, IISc Bangalore. He completed his Ph.D in 2018 and worked as a Research Associate in the same department. Currently, Dr. Imtiyaz is working as a post-doctoral fellow in King Abdullah University of Science and Technology (KAUST), Saudi Arabia. He shares his significant research works withRashida Bakait of India Tomorrow. Here are the excerpts of the interview.
Q. To begin with, please explain in brief to our readers about `Supramolecular Chemistry’ and the research works associated with the subject.
Ans. Nature has inspired scientists to exploit the potency of weak non-covalent interactions to form complex functional Supramolecules, with wide range of applications, which led to the birth of a new field of chemistry called ‘Supramolecular chemistry’ i.e. chemistry ‘beyond molecule’. Supramolecules are large complex molecules formed upon aggregation of smaller constituent building blocks through non-covalent interactions by a process called ‘self-assembly’. ‘Self-assembly’ is a spontaneous process where components, either separated or linked, reversibly form complex ordered aggregates without any external direction. Supramolecular chemistry has emerged as a broad field and has given rise to vast number of diverse structures by using a variety of non-covalent intermolecular interactions.
Over the past two decades, various methodologies of co-ordination driven self-assembly for the rational design of polygons and 3D supramolecular including tetrahedra, cubes, octahedra, cuboctahedra, and others have been developed. Enzymes, which are nature’s molecular containers, possess molecular pockets capable of binding substrates through non-covalent interactions and catalyze many important enzymatic reactions. Over the last two decades, with the advent of co-ordination driven self-assembly, the focus has greatly shifted to exploiting weak metal–ligand coordination for the self-assembly of molecular containers from individual components. The simple yet dynamic nature of coordination driven self-assembly has led to the construction of various capsules and cages with nanometre-size cavities capable of various applications. The shape and size of inner cavity of the coordination cages, even those not possessing definite covalent interactions between the catalyst and substrate, play a paramount role in altering the reactivity and properties of the contained molecules.
The central theme of my doctoral research interest in IISc has been in the area of co-ordination driven supramolecular chemistry, arguably one of the hottest areas of chemical sciences. In my research work at IISc Bangalore, I was specifically engaged in developing novel coordination cages possessing confined cavity and demonstrate their applications in cavity directed catalysis and stimuli-responsive targeted drug delivery.
Besides this, my current research focus at King Abdullah University of Science and technology, Saudi Arabia as Post-doctoral fellow is to design and synthesize the Imine-based macrocycle which will act as Non Adaptive Crystal Systems (NACs) and will eventually be used for separation of hydrocarbon and their derivatives. These Imine based macrocycles offer plenty of merits, such as easy preparation, low cost, high recyclability, chemical resistance, and thermal stability and hence makes them ideal material for industrial application.
Q. What was the objective of your research?
Ans. The supramolecular coordination complexes are obtained by mixing soluble metals as acceptors and ligand precursors as donors which spontaneously form metal-ligand bonds to generate a single thermodynamically-favoured product. Over the past two decades, various methodologies of coordination driven self-assembly for the rational design of polygons and 3D supramolecules including tetrahedra, cubes, octahedra, cuboctahedra, and others have been developed. My aim was to examine the self-assembly of pyridine and pyrimidine based ligands with square planar Pd(II) and Pt(II) metal ions to get the water soluble supramolecular structures with intrinsic hydrophobic cavity. These supramolecules with intrinsic hydrophobic cavity have a potential to function like the naturally found catalysts i.e enzymes by mimicking the cavity driven enzymatic reactions.
Q. When did you begin and complete your research?
Ans. I started in 2013 as a PhD student in Prof. P. S. Mukherjee lab at IISc Bangalore. Currently. I am working as a post-doctoral fellow in King Abdullah University of Science and Technology (KAUST), Saudi Arabia.
Q. What were the new findings of your research?
Ans. I could successfully synthesize and characterize various water soluble supramolecular structures with different shapes like sphere in sphere, tubes, tetrahedron, molecular barrels etc. and sizes. The tetrahedral cage with confined space was used as supramolecular catalyst to promote the Michael Addition Reaction of Indole and various nitro-styrene derivatives in water. The hydrophobic cavity of water soluble barrel like structures was successfully utilized to encapsulate curcumin and increased its solubility, enhanced its stability against UV light and thus acted as a safe aqueous carrier of curcumin to HeLa cancer cells. Also, an unusual supramolecule with triangular orthobicupola geometry was obtained, which is the first example of its type reported so far. The confined pocket of this cage with unique structural topology has been successfully used for the catalytic intramolecular cycloaddition reaction of substrates containing less reactive alkyne dienophile.
Q. What was the conclusion of your research?
Ans. In conclusion, we could successfully synthesize and characterize a giant double layered spherical structure with 24 Pd (Palladium) ions and 24 Pyrimidine based ligands. The strategy used here for the synthesis of double-shell superstructure establishes new guidelines for the creation of novel complex architectures. To further explore Pyrimidine as donors, various ligands with Pyrimidine as donors were synthesized and their self-assembly with cis-blocked Pt acceptor has led to formation of tube and tetrahedral cage structures. The tetrahedral cage with confined space was used as supramolecular catalyst to promote the Michael addition reaction of indole and various nitro-styrene derivatives. We were able to synthesize and characterize a water soluble barrel and cylindrical assemblies.The hydrophobic cavity of water soluble barrel was successfully utilized to encapsulate curcumin and increased its solubility, enhanced its stability against UV light and thus acted as a safe aqueous carrier of curcumin to HeLa cancer cells. The cylindrical assembly obtained was found to adopt an unusual triangular Orthobicupola geometry, which is the first example of its type reported so far. The confined pocket of this cage with unique structural topology has been successfully used for the catalytic intramolecular cycloaddition reaction of substrates containing less reactive alkyne dienophile.
Q. What kind of challenges did you face?
Ans. Challenges and difficulties are the inherent part of the research and researchers have to find ways to overcome them and materialize their tasks. It was really a herculean task in characterizing these supramolecular structures. However, patience and positive attitude helped me to keep trying and I could finally characterize them well and obtained their crystal structures. As a beginner, I struggled with writing my results and presenting them in scientific journals.
Q. Any scholarships or awards for research?
Ans. My Research Associateship was extended for one more year in IISc for completing research within five years. In 2019 I received Irish research post-doctoral fellowship in Trinity College, Dublin
Q. How do you think your research would be beneficial to the society or industry?
Ans. The 3D metallo-supramolecular architectures with confined cavity have been exploited for many applications such as- guest encapsulation, catalysis and drug delivery etc. we were able to show that organic chemical reactions can be performed in water using these water soluble supramolecular structures. Barrel shaped molecules are highly promising which possess large open windows along with large confined cavity. Our approach provides one of the elegant and efficient methods to design such barrel shaped architectures and their use to perform the catalytic organic transformation in aqueous medium. A lot of effort is going on in the scientific field to design new such systems and utilize them for various applications. The importance of this field could be easily reflected from the 2016 Nobel Prize which was awarded for novel findings in supramolecular chemistry.
Q. How do you think your research can be carried forward?
Ans. The features of coordination driven self-assembly like high directionality, intermediate bond enthalpy and vast diversity of organic ligands make it unique over the other non-covalent self-assembly approaches. The coordination-driven self-assembly was initiated by Lehn and Sauvage and pioneered the field with the introduction of various architectures ranging from ladders, helicases, rings, knots, rotaxanes, catenanes, and several other architectures. Later on, other scientists have taken the field to newer heights by developing novel methodologies and approaches to design and synthesize various discrete metal-organic architectures of distinct shapes, sizes and functionalities. The breadth of coordination driven self-assembly has continuously increased with the introduction of numerous functional supramolecules each year and it keeps on growing with every passing day.
Q. Any new research you are working on now?
Ans. My current research focus at King Abdullah university of Science and technology, Saudi Arabia as Post-doctoral fellow is to design and synthesize the Imine based macrocycle which will act as Non Adaptive Crystal Systems (NACs) and will eventually be used for separation of hydrocarbon and their derivatives. These Imine based macrocycles offer plenty of merits, such as easy preparation, low cost, high recyclability, chemical resistance, and thermal stability and hence makes them ideal material for industrial application.
Q. Give few suggestions to budding scientists.
Ans. For those who have decided to take research as their career, I would like to suggest them that patience is the key and keep learning from the mistakes as this is how it works in research. As a researcher, update yourself with the current literature related to your field that will help you to give new directions to your ongoing projects. Time management is crucial. Plan your experiments in advance so that you are confident about tasks you will be performing. Wishing goodluck to all budding scientists.
source: http://www.indiatomorrow.net / India Tomorrow / Home> Education> Featured / by Rashida Bakait, India Tomorrow / April 28th, 2021
Volunteers distributing food | Photo Credit: special arrangement
Mohd. Abdul Yousuf and his team of volunteers networked across the nation to help tackle the second wave of the pandemic
When Hyderabad-based Mohd. Abdul Yousuf, a fourth-year student of Symbiosis Law School in Hyderabad and his friends wanted to feed the needy hit by COVID-19, they could not afford to hire a chef at ₹1,200 per day to prepare a meal with 25 kilograms of rice. Undeterred, the boys watched cookery channels to learn to prepare it themselves. Now, the team of volunteers of Helping Humans Hyderabad founded by Abdul, packs 400 dinner boxes and distributes them at Tadbun, Charminar, Government Maternity Hospital in Afzal Gunj, Mahatma Gandhi Bus Station, Osmania General Hospital, Hyderabad Railway Station at Nampally, Public Gardens, MNJ̥ Cancer Hospital and Niloufer Hospital. “We make kaju, lemon and jeera rice and even made chicken biriyani sponsored by a friend,” says Abdul.
Mohd. Abdul Yousuf | Photo Credit: special arrangement
Helping Humans Hyderabad is among several voluntary organisations helmed by youngsters to verify leads, identify and share information on hospital resources and medical supplies to help tackle the second wave of the pandemic. However, Abdul’s organisation reached out beyond Hyderabad to Bengaluru, Gujarat, Delhi, Patna and Kerala as he networked from his contacts across India.
It started when Abdul posted a friend’s plasma request on his Instagram account. Buoyed by the response and backed by his associates: Lamya Hussaini, Molshree Totla and Ismail Zabiullah, he launched Helping Humans on April 16, his birthday, to amplify appeals for help. “We launched the page at 9 pm and at 1.30 am, we got a request for an oxygen cylinder,” he recalls.
Abdul and four core members of Helping Humans pooled ₹20,000 from their pockets to steer the network. With friends across India, he created a network of individuals to provide info from their cities; volunteers then verified the leads and updated the information on a Google spreadsheet. ‘If you are sitting idle at home, give your time to us,’ was their message on social media, inviting volunteers to be part of the initiative which had more than 200 members from across India. The office of Kavitha Kalvakuntla responded to their tweets for hospital resources; which not only helped in closing the requests, but also airlifting a passenger from Bihar to Hyderabad.
“Oxygen shortage was a major one during those dreadful two months,” shares Abdul, adding that his phone has not stopped ringing since April. Most of the 400 to 500 calls used to be for oxygen cylinders. The team purchased these cylinders for ₹60,000 from their own pockets. “Now the calls for cylinders have reduced to 50; and enquiries now are for oxygen concentrators.”
Abdul hopes to find more sponsors for their free food distribution programme. “We are glad we were able to make at least a small difference,” he concludes.
source: http://www.thehindu.com / The Hindu / Home> Society – Relief Work / by Neerja Murthy / Hyderabad – June 18th, 2021
Former Karnataka Minority Welfare Haj & Wakf minister and ex-BJP leader Prof Mumtaz Ali Khan passed away at his residence in Bengaluru in the early hours on Monday due to illnesses associated with old age. He was 94 years of age.
Khan, a sociology professor, who had taught at the University of Agricultural Sciences here, had contested the assembly election on a BJP ticket, from Bengaluru’s Jayamahal constituency in 2004. Though he lost the election, he was made the Minister for Minority Affairs, Haj, and Wakf by chief minister B S Yeddyurappa.
After Yeddyurappa quit BJP to form his short-lived Karnataka Janata Party (KJP), Khan joined the new front, only to quit it and join back the saffron party.
In 2013, when BJP announced the then Gujarat chief minister Narendra Modi as its Prime Ministerial candidate, Mumtaz Ali Khan joined the Congress party saying he was saddened by his party’s decision.
A self-avowed RSS admirer, Khan was the author of the book ‘Naa Kanda RSS’ (RSS which I have seen) in which he praised the leaders of the extremist outfit as nation builders and blamed the Congress party for allegedly misguiding Muslims towards it.
Under his tenure as the minority affairs minister, the government launched several schemes to provide financial assistance to minority students pursuing UPSC exams and provided overseas scholarships.
Khan and his family were running a free-school for the last three decades from his pension money and personal sources in memory of his late son.
Prof. Mumtaz Ali Khan is survived by his wife, one son, one daughter.
source: http://www.thecognate.com / The Cognate / Home> News / by Shaik Zakeer Hussain / June 07th, 2021
This is the seventh part of the series called `Scientist Says’ where we bring for our readers the significant and commendable research works of young scientists.
Dr. Mohammed Kausar Raza completed his M.Sc. in Inorganic Chemistry from Jamia Millia Islamia, Delhi and began his Ph.D. in the year 2015 with Prof. Akhil Chakravarthy lab, Inorganic and Physical Chemistry Dept., IISc, Bangalore. After completing his Ph.D in the year October 2019, he joined California Institute of Technology (Caltech) in the United States as a postdoctoral research fellow in January 2020. He shares his significant research works with Rashida Bakait of India Tomorrow. Here are the excerpts of the interview.
Q. Please give a brief explanation of your research.
Ans. My research interest mainly focuses on to locate the lesions with the help of [4Fe4S] cluster and their treatment using Pt-based anticancer agents. The research area is divided into two parts: (i) Investigating the chemical role of [4fe4S] cluster in eukaryotic proteins through electrochemical and biochemical studies. (ii) Use of Pt-based complexes for chemo phototherapeutic treatment of cancer.
Cancer is considered as one the deadliest diseases which has been outspreaded in various parts of the human body. Various methodologies have been implemented till date to fight against the proliferation of cancerous cells, namely, Chemotherapy (mainly Pt-based anticancer drugs), Photodynamic Therapy (which involves photosensitizer, light, molecular oxygen), etc. To fill the pitfalls of the conventional chemotherapeutic and photodynamic therapeutic drugs including the NER machinery and less tissue penetration respectively, during my PhD research at Indian Institute of Science, Bangalore, I combined these two well known modalities, i.e.; chemotherapy and photodynamic therapy (PDT) by tuning the structural properties of Pt-based complexes to kill the cancer cells selectively. The idea was to develop the series of conjugates bearing the structural framework as of the conventional chemotherapeutic anticancer drug, cisplatin and BODIPY dyes for PDT activity. In photodynamic therapy, the growth of cancer cells can be terminated in the presence of light which generates ROS (reactive oxygen species) capable of cleaving the DNA of the tumor cells and in turn causing the cell death. The cell imaging is beneficial to track the anti-cancer drug inside the body. The combination of the Pt metal which encrusted the path for DNA cross-linking and the BODIPY motif attached which aided in cell imaging and killing of cancer cells in the presence of light, comes out as a new scope to design the more efficient photodynamic chemotherapeutic anticancer agents.
Earlier in my PhD, I have made efforts to treat the cancer, now I am exploring my research to detect the lesions through DNA mediated charge transport chemistry. It focuses on assessing the functional role of iron sulfur [4Fe-4S] in eukaryotic DNA replicative and repair proteins. We perform the electrochemical investigation to detect the tumor/disordered sites using DNA mediated electron transfer.
Q. When did you begin and complete your research?
Ans. My research started with my master dissertation work in the year 2014. I started working as a PhD researcher in the January 2015 and successfully submitted my thesis in Oct. 2019. Now, I have been doing research as a postdoctoral fellow in the field of biochemistry since January 2020.
Q. What was the objective of your research?
Ans. Since a variety of anticancer drugs are known to treat numerous kinds of cancers, namely colorectal cancer, breast cancer, oral cancer, and lung cancer etc. My aim was to design and synthesize a drug in such a way which is highly selective towards killing the cancer cells without harming the normal living cells. We intended to approach a dual action mechanism of platinum based anticancer drugs for real time tracking and selective cancer cell death.
Q. What were the findings of your research?
Ans. We prepared a series of mono-functional Pt-based complexes capable of binding with DNA for the treatment against cancer. We have mainly designed the mitochondrial targeting anticancer drugs, as mitochondria is known as the powerhouse of the cell and it lack NER machinery. Major outcome of our studies is in the form of a indigenously synthesized prodrug which have 100-fold better anticancer activity than FDA approved Photofrin drug. Moreover, this drug can be tracked inside the cell which is not the case with any of the FDA approved platinum based anticancer drugs. We have conducted the in-vivo anticancer studies of these drugs in the living mice models using photodynamic chemotherapeutic dual action mechanism and obtained promising results which is turned out to be a patent in this emerging field. This work was done with the collaboration in the department of biological sciences at IISc.
Q. What was the conclusion of your research?
Ans. My work presents a thorough investigation on the Pt-based anticancer drugs derived from cisplatin motif. Appendment of BODIPY moieties as florescent probes aided in cell imaging and production of ROS to kill the cancer cells in presence of light. The in-depth photophysical investigation of our Pt based complexes revealed their properties to absorb visible light and made them suitable for real time tracking. This study provides further scope for combinatorial research that includes photodynamic therapy and DNA cross linking ability of the monofunctional Pt (II) drugs (chemotherapy) against cancer. Finally, the in vivo assay results on mice showed significant arrest of tumor growth and its shrinkage in size thus giving new insights in the chemistry of platinum-based PDT agents.
Q. What kind of challenges did you face?
Ans. In my masters, I have pursued a research project in coordination chemistry. I have learned various synthetic procedures to synthesize a variety of transition metal complexes and carried out an in-depth characterization using various spectroscopic techniques. Then I joined a bioinorganic chemistry lab, where the challenge was to design the metal complexes with a sharp focus on its pharmacology (pharmacokinetics) by implementing a cost-effective methodology. Also, the fluorophore motifs incorporated in the structure must have the significant absorption and emission photophysical properties which can aid the drug in penetrating deep inside the body. It was achieved after studying the UV-Vis properties of the drugs. Developing a drug performing a dual action mechanism in treating cancer cells was itself a challenge. Furthermore, I joined a biochemistry lab at Caltech, moving from bioinorganic to biochemistry was another major challenge, where I had to learn the new techniques and methods prior to performing the experiments and analyzing the outcomes.
Q. Any scholarships or awards for research?
Ans. As the recognition of my doctoral work, I received the prestigious Carl Storm International Diversity (CSID) fellowship for Gordon Research Conference (GRC), Metal in Medicine, USA. I am also a recipient of “Government of India International Travel Research Award (DST), CSIR Travel Research Award, ICMR Travel Research Award, SBIC Student Travel Grants for ICBIC-19 in Interlaken, Switzerland. I received fellowship from MHRD and CSIR for the five year during my Ph.D.
Q. How do you think your research would be beneficial to the society or industry?
Ans.Cancer counts among the second deadliest diseases in the world. Among all types of cancer, about 30% of India’s affected population accounts for oral cancer only. Among the various therapies established for cancer treatment, photodynamic therapy is well known for the treatment of oral cancer. My research on Pt based drugs will provide a new insight and scope to combine the two therapies and kill the tumor with notable potency. Our mice model demonstrated an excellent efficacy of our drug inside the living being. These new findings can lead to investigate the drug-tumor interaction inside the human body. Implementation of our Pt based prodrugs will provide a new way to treat the cancer. Moreover, commercializing these drugs may reduce the cost of treatment. In addition, it’s manufacturing at industrial level will increase the employment for several educated and skilled people in our country.
Q. Any new research you are working on now?
Ans. Currently, I am working on the DNA mediated charge (electron) transfer chemistry. My aim is to investigate the rapid communication among DNA-processing proteins for repairment through DNA-mediated redox signaling. These DNA-processing enzymes bear an iron-sulfur [4Fe4S] cluster which performs common redox switch on binding with DNA and gives rise to DNA-charge transport chemistry. It mainly focuses on the electrochemical investigation of the chemical role of the [4Fe4S] cluster in eukaryotic DNA primase and the polymerase. Importantly, electrochemistry on the DNA-modified electrodes facilitates reaction under aqueous, physiological conditions with a sensitive electrical measurement of binding and activity.
Q. How do you think your research can be carried forward?
Ans. Organelle targeting is an emerging field and needs thorough investigation to study the action of metallodrug inside the biological systems. Introducing selectivity in structural framework of the drugs towards single organelle targeting can make the drug more potent and viable. Other metals are also prominent on anticancer platform, so it is possible to design and synthesize such cost effective and biocompatible metal ligand frameworks which is capable of performing multiple actions with significant potency. The preliminary in vivo results and pharmacokinetics suggested that a detailed study need to perform so that it can be taken to clinical trial.
Q. Give some suggestions to the budding scientists.
Ans. Academia is a never-ending journey full of exciting adventures. It should be spent with utmost pleasure and satisfaction while enjoying science. One should be able to eminence both the personal affairs and professional business. Be clear and rational. Do not hesitate while expressing and talking about yourself, be it stress or mental health imbalance. Also, create another world outside the lab and explore it. Hone your communication skills. In academia, communication is the key to success Always indulge in a teamwork, moreover, in order to be an interdisciplinary scientist, be open to accept and request for collaboration. Do something different which no one thinks is important and invest your efforts and time in it. Learn broadly. Be bold. Be passionate. Establish a name for yourself. Above all, perhaps, to be successful in academia you need to develop your persistence and preserve your creativity no matter what. The key to unlocking the untapped potential is to create and build a path conducive to novelty in science. Make your research plans wisely and execute them in a disciplined way. Always remember, slow and steady wins the race.
source: http://www.indiatomorrow.net / India Tomorrow / Home> Education / by Rashida Bakait, India Tomorrow / May 01st, 2021
Known as the Oxygen Man of Hyderabad, Mohammed Sujathullah has been waging a war against hunger for more than four years. People started calling him Oxygen Man following him providing free oxygen cylinders to more than 1000 persons suffering from coronavirus.
Mohammed Sujathullah has been arranging free breakfast for 1000 people for the last four and a half years without missing a single day, in three government hospitals–King Koti Maternity Hospital, Sultan Bazaar, Niloufer Hospital, Red Hills, and NIMS, Punjagutta. He has also been providing dinner to homeless people on the roadsides for the past year.
Mohammed Sujathullah spoke to siasat.com about his journey to help people. He also spoke about what motivated and inspired him. He also shared his future plans in the fight against hunger.
Journey
Though he studied up to fifth grade, he could learn only the use of English alphabets. “I don’t know whether it was a favor from the school to promote me from one class to another. I crawled up to the fifth standard but hardly learned anything,” he remembered.
Then came the turnaround. But he doesn’t know-how. He suddenly began focusing on studies and worked vigorously to get into B. Pharmacy in Sultan Uloom College. In the third year of the course in 2015, he realized that he has to clear an Organic Chemistry backlog which he was a tough subject for him.
He could somehow clear that subject in one of the re-examinations he wrote. Sujathullah had vowed that if he clears the examination he would feed 10 persons. Following the results remembered his vow and bought 10 food packets from his meager savings and gave them away.
“In 24 years of my life, I had never felt as happy as I did when I fed hungry persons,” Sujathullah said after his experience in charity. He went to distribute food at a railway station and found himself in a situation where he had only 4 packets and there were 15-20 hungry people looking at me expectantly.
“That’s when I realized what hunger is. I realized how privileged I was to have been born into a family where all my wishes were fulfilled by my parents,” Sujathullah added. He said that this was when he decided to start distributing food on a daily basis. That was the beginning of his journey.
Since he lived in a joint family, he told everyone what he was planning to do. His family members decided to pledge a part of their monthly earnings to feed the hungry. In 2015-16 he distributed food four times a week with the help of his friends. We started doing a supper distribution program beginning with 50 food packs and slowly reached up to 200.
During his years in Pharm. D, he wasn’t able to take time out for social service. Later he came up with the idea of organizing breakfasts. “I could benefit more people with a smaller budget,” he said.
He said that he started distributing food packets at a government hospital and later added more distribution points.
Until now he has completed 1700 days. Also, now he has been organizing breakfasts for people at three government hospitals without missing a single day.
Encouraged by the support and success of his work, Sujathullah founded an NGO, Humanity First Foundation. He is now working on various other issues.
He said that he manages the funds with the help of crown funding with a 100% donation system i.e., his NGO. At the same time, he doesn’t take any money for himself.
“Everyone has something special within himself or herself. They should recognize and use it. Pay attention to the life after death, and become a good human,” Sujathullah advises.
Future plans
“Currently we are organizing water camps at bus stops. Since the beginning of the pandemic we have arranged groceries and lunch for the migrant workers,” he informed.
Since the beginning of the pandemic last year his organization has bought 400 oxygen cylinders and 30 concentrators to benefit the people.
source: http://www.siasat.com / The Siasat Daily / Home> News> Hyderabad News / by Usama Hazari / June 21st, 2021
MANUU awards PhD in Journalism to Arif Moin on Monday.
Hyderabad:
The Maulana Azad National Urdu University on Monday declared Arif Moin qualified in Doctor of Philosophy in Journalism and Mass Communication.
Moin has worked on the topic “Socio-Cultural, Political and Religious Impact of Urdu Satellite TV Channels on Indian Muslims” under the supervision of Prof. Ehtesham Ahmed Khan, Dean, School of Mass Communication & Journalism.
The research topic covered four Urdu channels – ETV Urdu, Door Darshan Urdu Channel, Zee Salam and Munsif TV. Arif Moin has extensive experience in TV production and has been associated in various capacities with the programming department of ETV Urdu and News18 Urdu.
Maulana Azad National Urdu University (MANUU) has started online admission process for the year 2021-2022 into its various programmes being offered at Hyderabad headquarters, Lucknow and Srinagar (J&K) campuses and colleges of Teacher Education (CTEs) and Polytechnics spread in different parts of the country.
